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Hypothesis-driven intervention: microbial IAA activates AHR, potentiates PARP1 PARylation, improves barrier function, suppresses inflammation/senescence. Focus: genome maintenance as a tissue-ecology property.
Reframe: geroprotectors may reduce lesion burden (e.g., γH2AX) alongside classic autophagy narratives. Focus: damage formation vs repair capacity tradeoffs in immune subsets.